Vcorn SARS-CoV-2
Database of viral gene mutation

★ G446S
 ♦ Profile
Specimens cDNA 3-letter
amino acid		 1-letter
amino acid		 The earliest specimen
Specimen ID Collectin date Geographical location
127,604 c.1336G>A Gly446Ser G446S FR995343.1 2020-04-04 United Kingdom
ON637182.1 2021-12-08 United States
 ♦ WHO labeled variants
WHO label Designation Pango lineage Specimen Share
Alpha VOC B.1.1.7 0 % ( 37 / 542530 )
Beta VOC B.1.351 0 % ( 0 / 7535 )
Gamma VOC P.1 0 % ( 0 / 26941 )
Delta VOC B.1.617.2 0 % ( 558 / 2560363 )
Epsilon Unmonitored B.1.427 0 % ( 2 / 41381 )
Zeta Unmonitored P.2 0 % ( 0 / 1291 )
Eta Unmonitored B.1.525 0 % ( 0 / 2466 )
Theta Unmonitored P.3 0 % ( 0 / 43 )
Iota Unmonitored B.1.526 0 % ( 9 / 33075 )
Kappa Unmonitored B.1.617.1 0 % ( 0 / 554 )
Lambda VOI C.37 0 % ( 0 / 1315 )
Mu VOI B.1.621 0 % ( 0 / 5500 )
Omicron VOC B.1.1.529 5 % ( 126661 / 2333319 )


 ♦ Network between major mutations
D614G:5948563 T478K:3693517 P681H:2893569 G142D:2819456 L452R:2670051 P681R:2563035 T19R:2527655 D950N:2480832 E156fs:2396369 H655Y:2354889 N969K:2327356 T95I:2323542 Q954H:2316229 N679K:2316028 D796Y:2310375 D1146D:2285693 N764K:2138247 I68fs:1892405 N501Y:1755762 L981F:1251457 N856K:1246232 S477N:1219478 G339D:1218185 Y505H:1179592 E484A:1179233 G142fs:1177428 Q498R:1177162 S375F:1167506 S373P:1167354 N211fs:1166427 K417N:1123423 N440K:1096335 T19I:1069955 V213G:1064283 Q493R:1060854 D215fs:1051876 L24fs:1038801 R408S:1033237 A67V:1033211 T376A:1029269 D405N:1028502 S371F:1027310 V143fs:552113 A570D:544169 D1118H:543063 T716I:541773 S982A:537172 T547K:204408 A701V:150226 S704L:142578 G496S:141436 S371L:133639 L452Q:128246 G446S:127604 F486V:118985 L5F:115985 R346K:112161 L18F:80676 E484K:71650 S13I:40770 W152C:39420 D253G:37087 Q677H:35544 P26S:34458 V1176F:33647 K417T:33540 T1027I:32226 D138Y:32088 T20N:26519 R190S:25039 T76I:18184 T859N:13531 D215G:8640 T240fs:8158 H1101Y:8088 W152R:7846 D80A:7813 E484Q:6985 G75V:6718 Y145N:4884 Y144S:4776 F490S:4308 F157L:3674 Q52R:2805 F888L:2593 G257S:1599 R246fs:1235 Q1071H:995 I210V:471 K147E:430 E1092K:141 N460K:112 G339H:84
  D614G (gray); alpha (purple); beta (cyan); gamma (green); delta (orange); omicron (red);
  related to alpha (lavender); related to beta (lightcyan); related to delta (moccasin); others (darkgray)
  Black dot: mutation of interest; mutation in red or gray characters: coexistent in ≥50% or <50% specimens

 ♦ Coexistence
N211fs
F486V
K417N
S373P
S375F
G339D
Y505H
L452Q
G142fs
E484A
A67V
T376A
G496S
S477N
N856K
T19I
S371L
L981F
N764K
I68fs
D1146D
D950N
Q498R
T716I
P681R
N679K
Q954H
E156fs
T19R
A701V
L5F
T547K
S704L
P681H
R408S
D796Y
L452R
Q493R
N969K
H655Y
T95I
R346K
G142D
T1027I
K417T
D405N
Q677H
D215G
V213G
D614G
D215fs
D138Y
T478K
F888L
Y144S
F157L
T859N
R190S
L24fs
D253G
T20N
S982A
W152R
W152C
V1176F
F490S
H1101Y
N501Y
G257S
Y145N
N440K
T76I
T240fs
Q52R
G75V
V143fs
A570D
D1118H
E484K
L18F
S371F
P26S
D80A
R246fs
S13I
E484Q
I210V
Q1071H
K147E
E1092K
N460K
G339H
  Maroon mutated; Orange unclear about mutation; Yellow not mutated;


 ♦ Monthly chart
2020 Jan. Feb. Mar. Apr. May Jun. Jul. Aug. Sep. Oct. Nov. Dec. 2021 Jan. Feb. Mar. Apr. May Jun. Jul. Aug. Sep. Oct. Nov. Dec. 2022 Jan. Feb. Mar. Apr. May Jun. Jul. Aug. Sep. Oct. Nov. Dec. 0 10 20 30 40 50 60 70 80 90 100 Mutation ratio (%) Jan 2020, 0 (0%) Feb 2020, 0 (0%) Mar 2020, 0 (0%) Apr 2020, 2 (0%) May 2020, 2 (0%) Jun 2020, 0 (0%) Jul 2020, 0 (0%) Aug 2020, 4 (0%) Sep 2020, 0 (0%) Oct 2020, 0 (0%) Nov 2020, 2 (0%) Dec 2020, 31 (0%) Jan 2021, 10 (0%) Feb 2021, 20 (0%) Mar 2021, 20 (0%) Apr 2021, 9 (0%) May 2021, 12 (0%) Jun 2021, 3 (0%) Jul 2021, 7 (0%) Aug 2021, 29 (0%) Sep 2021, 64 (0%) Oct 2021, 149 (0%) Nov 2021, 265 (0%) Dec 2021, 30807 (5%) Jan 2022, 59995 (9%) Feb 2022, 29958 (6%) Mar 2022, 5386 (1%) Apr 2022, 494 (0%) May 2022, 65 (0%) Jun 2022, 103 (0%) Jul 2022, 51 (0%)


 ♦ Global map
/* * Ocean & lake */ /* * Each country/territory/region *//* * id="af", Afghanistan */ Afghanistan: 0 (0%) /* * id="al", Albania */ Albania: 0 (0%) /* * id="dz", Algeria */ Algeria: 0 (0%) /* * id="as", American Samoa (US) */ American Samoa (US): 0 (0%) /* * id="ad", Andorra */ /* * id="ao", Angola */ Angola: 0 (0%) /* * id="ai", Anguilla (UK) */ Anguilla (UK): 0 (0%) /* * id="aq", Antarctica */ Antarctica: 0 (0%) /* * id="ag", Antigua and Barbuda */ Antigua and Barbuda: 0 (0%) /* * id="ar", Argentina */ Argentina: 8 (6%) /* * id="am", Armenia */ Armenia: 0 (0%) /* * id="aw", Aruba (Netherlands) */ Aruba (Netherlands): 0 (0%) /* * id="au", Australia */ Australia: 2 (0%) /* * id="at", Austria */ Austria: 5 (1%) /* * id="az", Azerbaijan */ Azerbaijan: 0 (0%) /* * id="bs", Bahamas */ Bahamas: 0 (0%) /* * id="bh", Bahrain */ Bahrain: 84 (0%) /* * id="bd", Bangladesh */ Bangladesh: 40 (2%) /* * id="bb", Barbados */ Barbados: 0 (0%) /* * id="by", Belarus */ Belarus: 0 (0%) /* * id="be", Belgium */ Belgium: 0 (0%) /* * id="bz", Belize */ Belize: 0 (0%) /* * id="bj", Benin */ Benin: 0 (0%) /* * id="bm", Bermuda (UK) */ Bermuda (UK): 0 (0%) /* * id="bt", Bhutan */ Bhutan: 0 (0%) /* * id="bo", Bolivia */ Bolivia: 0 (0%) /* * id="ba", Bosnia and Herzegovina */ Bosnia and Herzegovina: 0 (0%) /* * id="bw", Botswana */ Botswana: 0 (0%) /* * id="br", Brazil */ Brazil: 115 (1%) /* * id="bn", Brunei */ Brunei: 0 (0%) /* * id="bg", Bulgaria */ Bulgaria: 0 (0%) /* * id="bf", Burkina Faso */ Burkina Faso: 0 (0%) /* * id="bi", Burundi */ Burundi: 0 (0%) /* * id="cv", Cape Verde */ Cape Verde: 0 (0%) /* * id="kh", Cambodia */ Cambodia: 0 (0%) /* * id="cm", Cameroon */ Cameroon: 0 (0%) /* * id="ca", Canada */ Canada: 0 (0%) /* * id="ky", Cayman Islands (UK) */ Cayman Islands (UK): 0 (0%) /* * id="cf", Central African Republic */ Central African Republic: 0 (0%) /* * id="td", Chad */ Chad: 0 (0%) /* * id="cl", Chile */ Chile: 0 (0%) /* * id="cn", China */ China: 0 (0%) /* * id="co", Colombia */ Colombia: 21 (0%) /* * id="km", Comoros */ Comoros: 0 (0%) /* * id="cg", Congo */ Congo: 0 (0%) /* * id="cd", DR Congo */ DR Congo: 0 (0%) /* * id="ck", Cook Islands (NZ) */ Cook Islands (NZ): 0 (0%) /* * id="cr", Costa Rica */ Costa Rica: 0 (0%) /* * id="ci", Ivory Coast */ Ivory Coast: 0 (0%) /* * id="hr", Croatia */ Croatia: 0 (0%) /* * id="cu", Cuba */ Cuba: 0 (0%) /* * id="cy", Cyprus */ Cyprus: 0 (0%) /* * id="cz", Czech Republic */ Czech Republic: 0 (0%) /* * id="dk", Denmark */ Denmark: 12,117 (3%) /* * id="dj", Djibouti */ Djibouti: 0 (0%) /* * id="dm", Dominica */ Dominica: 0 (0%) /* * id="do", Dominican Republic */ Dominican Republic: 0 (0%) /* * id="ec", Ecuador */ Ecuador: 0 (0%) /* * id="eg", Egypt */ Egypt: 0 (0%) /* * id="sv", El Salvador */ El Salvador: 0 (0%) /* * id="gq", Equatorial Guinea */ Equatorial Guinea: 0 (0%) /* * id="er", Eritrea */ Eritrea: 0 (0%) /* * id="ee", Estonia */ Estonia: 0 (0%) /* * id="sz", Eswatini */ Eswatini: 0 (0%) /* * id="et", Ethiopia */ Ethiopia: 0 (0%) /* * id="fk", Falkland Islands (UK) */ Falkland Islands (UK): 0 (0%) /* * id="fo", Faroe Islands (Denmark) */ Faroe Islands (Denmark): 0 (0%) /* * id="fj", Fiji */ Fiji: 0 (0%) /* * id="fi", Finland */ Finland: 0 (0%) /* * id="fr", France */ France: 796 (1%) /* * id="pf", French Polynesia (France) */ French Polynesia (France): 0 (0%) /* * id="ga", Gabon */ Gabon: 0 (0%) /* * id="gm", Gambia */ Gambia: 0 (0%) /* * id="ge", Georgia */ Georgia: 0 (0%) /* * id="de", Germany */ Germany: 23,309 (4%) /* * id="gh", Ghana */ Ghana: 0 (0%) /* * id="gi", Gibraltar (UK) */ Gibraltar (UK): 0 (0%) /* * id="gr", Greece */ Greece: 0 (0%) /* * id="gl", Greenland (Denmark) */ Greenland (Denmark): 0 (0%) /* * id="gd", Grenada */ Grenada: 0 (0%) /* * id="gu", Guam (US) */ Guam (US): 0 (0%) /* * id="gt", Guatemala */ Guatemala: 0 (0%) /* * id="gg", Guernsey (UK) */ Guernsey (UK): 0 (0%) /* * id="gn", Guinea */ Guinea: 0 (0%) /* * id="gw", Guinea-Bissau */ Guinea-Bissau: 0 (0%) /* * id="gy", Guyana */ Guyana: 0 (0%) /* * id="ht", Haiti */ Haiti: 0 (0%) /* * id="va", Vatican City */ Vatican City: 0 (0%) /* * id="hn", Honduras */ Honduras: 0 (0%) /* * id="hu", Hungary */ Hungary: 0 (0%) /* * id="is", Iceland */ Iceland: 0 (0%) /* * id="in", India */ India: 20 (0%) /* * id="id", Indonesia */ Indonesia: 0 (0%) /* * id="ir", Iran */ Iran: 0 (0%) /* * id="iq", Iraq */ Iraq: 3 (0%) /* * id="ie", Ireland */ Ireland: 0 (0%) /* * id="im", Isle of Man (UK) */ Isle of Man (UK): 0 (0%) /* * id="il", Israel */ Israel: 0 (0%) /* * id="it", Italy */ Italy: 1 (0%) /* * id="jm", Jamaica */ Jamaica: 0 (0%) /* * id="jp", Japan */ /* * id="je", Jersey (UK) */ Jersey (UK): 0 (0%) /* * id="jo", Jordan */ Jordan: 0 (0%) /* * id="kz", Kazakhstan */ Kazakhstan: 0 (0%) /* * id="ke", Kenya */ Kenya: 33 (0%) /* * id="ki", Kiribati */ Kiribati: 0 (0%) /* * id="kp", North Korea */ North Korea: 0 (0%) /* * id="kr", South Korea */ South Korea: 0 (0%) /* * id="kw", Kuwait */ Kuwait: 0 (0%) /* * id="kg", Kyrgyzstan */ Kyrgyzstan: 0 (0%) /* * id="la", Laos */ Laos: 0 (0%) /* * id="lv", Latvia */ Latvia: 0 (0%) /* * id="lb", Lebanon */ Lebanon: 0 (0%) /* * id="ls", Lesotho */ Lesotho: 0 (0%) /* * id="lr", Liberia */ Liberia: 0 (0%) /* * id="ly", Libya */ Libya: 0 (0%) /* * id="li", Liechtenstein */ Liechtenstein: 189 (14%) /* * id="lt", Lithuania */ Lithuania: 0 (0%) /* * id="lu", Luxembourg */ Luxembourg: 0 (0%) /* * id="mg", Madagascar */ Madagascar: 0 (0%) /* * id="mw", Malawi */ Malawi: 0 (0%) /* * id="my", Malaysia */ Malaysia: 44 (10%) /* * id="mv", Maldives */ Maldives: 0 (0%) /* * id="ml", Mali */ Mali: 0 (0%) /* * id="mt", Malta */ Malta: 0 (0%) /* * id="mh", Marshall Islands */ Marshall Islands: 0 (0%) /* * id="mr", Mauritania */ Mauritania: 0 (0%) /* * id="mu", Mauritius */ Mauritius: 0 (0%) /* * id="yt", Mayotte */ Mayotte: 0 (0%) /* * id="mx", Mexico */ Mexico: 3 (0%) /* * id="fm", F.S. Micronesia */ F.S. Micronesia: 0 (0%) /* * id="md", Moldova */ Moldova: 0 (0%) /* * id="mc", Monaco */ Monaco: 0 (0%) /* * id="mn", Mongolia */ Mongolia: 0 (0%) /* * id="me", Montenegro */ Montenegro: 0 (0%) /* * id="ms", Montserrat (UK) */ Montserrat (UK): 0 (0%) /* * id="ma", Morocco */ Morocco: 0 (0%) /* * id="mz", Mozambique */ Mozambique: 0 (0%) /* * id="mm", Myanmar */ Myanmar: 0 (0%) /* * id="na", Namibia */ Namibia: 0 (0%) /* * id="nr", Nauru */ Nauru: 0 (0%) /* * id="np", Nepal */ Nepal: 0 (0%) /* * id="nl", Netherlands */ Netherlands: 0 (0%) /* * id="nc", New Caledonia (France) */ New Caledonia (France): 0 (0%) /* * id="nz", New Zealand */ New Zealand: 0 (0%) /* * id="ni", Nicaragua */ Nicaragua: 0 (0%) /* * id="ne", Niger */ Niger: 0 (0%) /* * id="ng", Nigeria */ Nigeria: 0 (0%) /* * id="nu", Niue (NZ) */ Niue (NZ): 0 (0%) /* * id="mk", North Macedonia */ North Macedonia: 0 (0%) /* * id="mp", Northern Mariana Islands (US) */ Northern Mariana Islands (US): 0 (0%) /* * id="no", Norway */ Norway: 0 (0%) /* * id="om", Oman */ Oman: 0 (0%) /* * id="pk", Pakistan */ Pakistan: 6 (0%) /* * id="pw", Palau */ Palau: 0 (0%) /* * id="ps", Palestine */ Palestine: 17 (16%) /* * id="pa", Panama */ Panama: 0 (0%) /* * id="pg", Papua New Guinea */ Papua New Guinea: 0 (0%) /* * id="py", Paraguay */ Paraguay: 0 (0%) /* * id="pe", Peru */ Peru: 14 (3%) /* * id="ph", Philippines */ Philippines: 0 (0%) /* * id="pn", Pitcairn Islands (UK) */ Pitcairn Islands (UK): 0 (0%) /* * id="pl", Poland */ Poland: 0 (0%) /* * id="pt", Portugal */ Portugal: 0 (0%) /* * id="pr", Puerto Rico (US) */ Puerto Rico (US): 2 (0%) /* * id="qa", Qatar */ Qatar: 0 (0%) /* * id="ro", Romania */ Romania: 0 (0%) /* * id="ru", Russia */ Russia: 3 (0%) /* * id="rw", Rwanda */ Rwanda: 0 (0%) /* * id="bl", Saint Barthelemy (France) */ Saint Barthelemy (France): 0 (0%) /* * id="sh", Saint Helena, Ascension and Tristan da Cunha (UK) */ Saint Helena, Ascension and Tristan da Cunha (UK): 0 (0%) /* * id="kn", Saint Kitts and Nevis */ Saint Kitts and Nevis: 0 (0%) /* * id="lc", Saint Lucia */ Saint Lucia: 0 (0%) /* * id="mf", Saint Martin (France) */ Saint Martin (France): 0 (0%) /* * id="pm", Saint Pierre and Miquelon (France) */ Saint Pierre and Miquelon (France): 0 (0%) /* * id="vc", Saint Vincent and the Grenadines */ Saint Vincent and the Grenadines: 0 (0%) /* * id="ws", Samoa */ Samoa: 0 (0%) /* * id="sm", San Marino */ San Marino: 0 (0%) /* * id="st", Sao Tome and Principe */ Sao Tome and Principe: 0 (0%) /* * id="sa", Saudi Arabia */ Saudi Arabia: 0 (0%) /* * id="sn", Senegal */ Senegal: 0 (0%) /* * id="rs", Serbia */ Serbia: 0 (0%) /* * id="sc", Seychelles */ Seychelles: 2 (0%) /* * id="sl", Sierra Leone */ Sierra Leone: 0 (0%) /* * id="sg", Singapore */ Singapore: 0 (0%) /* * id="sk", Slovakia */ Slovakia: 2,006 (6%) /* * id="si", Slovenia */ Slovenia: 0 (0%) /* * id="sb", Solomon Islands */ Solomon Islands: 0 (0%) /* * id="so", Somalia */ Somalia: 0 (0%) /* * id="za", South Africa */ South Africa: 7 (0%) /* * id="ss", South Sudan */ South Sudan: 0 (0%) /* * id="es", Spain */ Spain: 0 (0%) /* * id="lk", Sri Lanka */ Sri Lanka: 0 (0%) /* * id="sd", Sudan */ Sudan: 0 (0%) /* * id="sr", Suriname */ Suriname: 0 (0%) /* * id="se", Sweden */ Sweden: 0 (0%) /* * id="ch", Switzerland */ Switzerland: 6,037 (4%) /* * id="sy", Syria */ Syria: 0 (0%) /* * id="tw", Taiwan */ Taiwan: 0 (0%) /* * id="tj", Tajikistan */ Tajikistan: 0 (0%) /* * id="tz", Tanzania */ Tanzania: 0 (0%) /* * id="th", Thailand */ Thailand: 64 (1%) /* * id="tl", East Timor */ East Timor: 0 (0%) /* * id="tg", Togo */ Togo: 0 (0%) /* * id="to", Tonga */ Tonga: 0 (0%) /* * id="tt", Trinidad and Tobago */ Trinidad and Tobago: 0 (0%) /* * id="tn", Tunisia */ Tunisia: 0 (0%) /* * id="tr", Turkey */ Turkey: 0 (0%) /* * id="tm", Turkmenistan */ Turkmenistan: 0 (0%) /* * id="tc", Turks and Caicos Islands (UK) */ Turks and Caicos Islands (UK): 0 (0%) /* * id="tv", Tuvalu */ Tuvalu: 0 (0%) /* * id="ug", Uganda */ Uganda: 0 (0%) /* * id="ua", Ukraine */ Ukraine: 0 (0%) /* * id="ae", United Arab Emirates */ United Arab Emirates: 0 (0%) /* * id="gb", United Kingdom */ United Kingdom: 1,882 (0%) /* * id="us", United States */ United States: 80,471 (3%) /* * id="uy", Uruguay */ Uruguay: 0 (0%) /* * id="uz", Uzbekistan */ Uzbekistan: 0 (0%) /* * id="vu", Vanuatu */ Vanuatu: 0 (0%) /* * id="ve", Venezuela */ Venezuela: 0 (0%) /* * id="vn", Vietnam */ Vietnam: 4 (0%) /* * id="vg", British Virgin Islands (UK) */ British Virgin Islands (UK): 0 (0%) /* * id="vi", U.S. Virgin Islands (US) */ U.S. Virgin Islands (US): 0 (0%) /* * id="wf", Wallis and Futuna (France) */ Wallis and Futuna (France): 0 (0%) /* * id="eh", Western Sahara */ Western Sahara: 0 (0%) /* * id="ye", Yemen */ Yemen: 0 (0%) /* * id="zm", Zambia */ Zambia: 0 (0%) /* * id="zw", Zimbabwe */ Zimbabwe: 0 (0%)
Gray: unsampled; White: <100 specimens; Yellow: <25%; Orange: <:50%; Red: <75%; Maroon: <100%; Black: 100%